Stemming opioid deaths


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Stemming opioid deaths

Toronto, November 2, 2017

By Geoff Koehler

Dr. Gaspard Montandon
Dr. Gaspard Montandon, a researcher within the Keenan Research Center for Biomedical Science, states that to lessen opioid overdose deaths, Canadians have to change from reacting for them to stopping them in a cellular level. (Photo by Katie Cooper)

A brand new investigator with St. Michael’s Keenan Research Center for Biomedical Science really wants to steer clear of the nearly 2,500 opioid-related deaths in Canada each year by looking into making the drugs less deadly.

“Opioid overdose kills by shutting lower the mind and also the respiratory system system, but nobody knows just how that occurs in a cellular level,” stated Dr. Gaspard Montandon, with a PhD centered on the outcome of medication on breathing. “With a much better knowledge of what’s happening within the brain throughout an overdose, I believe we might be able to locate an antidote that stops the lethal side-results of opioids while preserving their painkiller effects.”

Dr. Montandon stated that naloxone—the existence-saving drug provided to those who are getting an opioid overdose—is a highly effective therapy that needs to be broadly available and used, however, it’s unable to prevent opioid overdose. It may be given once an overdose has happened.

His look for an antidote to opioid overdose has brought Dr. Montandon to recognize proteins within the brain which may be potential therapeutic targets. By collaborating with several researchers in the hospital, including Dr. Xiao-Yan Wen from the Zebrafish Center for Advanced Drug Discovery, Dr. Montandon is creating a platform to recognize the genes accountable for people’s existence-threatening reaction to opioids. He intends to test a range of drugs within the lab that may avoid the respiratory system depression that shuts lower the mind and inhaling overdoses.

      Related research
Dr. Tara Gomes, a researcher with St. Michael’s Ontario Drug Policy Research Network, lately printed research showing the size from the opioid epidemic in Ontario. She demonstrated that a couple die every day in Ontario because of opioid overdoses.

“If we uncover the genes accountable for causing respiratory system depression when met with opioids, we’ll have great insights into which proteins lead to making opioid overdose deadly,” stated Dr. Montandon. “We could make opioid therapy safer by developing drugs that alter the way our brain’s breathing circuitry reacts to opioids and hopefully prevent these drugs from shutting lower the mind and breathing.”

During the last twenty five years, deaths associated with opioid prescriptions in Ontario have nearly quadrupled. Dr. Montandon stated his quest would be to dramatically reduce that trend.

About St. Michael’s Hospital

St. Michael’s Hospital provides compassionate choose to all who enter its doorways. A healthcare facility offers outstanding medical education to future medical professionals in additional than 29 academic disciplines. Critical care and trauma, cardiovascular disease, neurosurgery, diabetes, cancer care, proper care of the destitute and global health are some of the Hospital’s recognized special areas of practice. With the Keenan Research Center and also the Li Ka Shing Worldwide Healthcare Education Center, which from the Li Ka Shing Understanding Institute, research and education at St. Michael’s Hospital are recognized making an effect all over the world. Founded in 1892, a healthcare facility is fully associated with the College of Toronto.

Kick-start healthier eating this month


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Kick-start healthier eating this month

Toronto, March 1, 2016

By Becca Goss

Dr. Nicholas Vozoris

You will find over 30 registered dietitians employed throughout St. Michael’s, from pediatrics towards the ICU, who use patients to make sure they receive proper diet within the hospital and hang up diet plans when ever they leave.

March is Diet Month, so there’s no better time for you to set your personal diet goals and begin making plans towards healthier eating. With the aid of Dietitians Canada, listed here are five ideas to start maintaining a healthy diet:

Tip 1 – Prepare

Start your eating healthily goals by reflecting on your food intake every day. Concentrate on making one small change and sticking with it, rather of attempting to alter everything at the same time. Go one meal at any given time. Committing to create a healthy change is a superb initial step.

Learn more info on getting ready for much better eating.

Tip 2 – Quality counts

With regards to diet, quality counts. Adding nourishment to foods promote health insurance and will help you feel your very best. Take small steps to boost the caliber of your snacks and meals: get clever with cooking, swap in nutrient-wealthy choices and revel in deliciously well balanced meals.

Below are great tips to help you get began.

Tip 3 – Prioritize portion size

With regards to eating healthily, just how much you consume could be just as essential as your food intake. Eating portions which are too large can result in overeating and putting on weight. Manage serving sizes by calculating together with your hands and fingers, using smaller sized plates and switching off screens when you eat.

Follow these suggestions to manage the munchies while enjoying realistic portions.

Tip 4 – Try something totally new

Think eating healthily is bland? Not a way! Eating healthily tastes great! Ensure that it stays interesting: get creative with cooking strategies, test out new flavours and refresh your recipes.

Get inspired.

Tip 5 – Allow it to be stick

Insufficient time, eating at restaurants, holidays, stress? Everyone has challenges that may sidetrack our eating healthily plans. Keeping kitchen cupboards stocked with healthy snacks and getting your lunch to operate are a couple of efficient ways to stick to your diet goals.

Listed here are more ways of strengthen your small changes stick.

About St. Michael’s Hospital

St. Michael’s Hospital provides compassionate choose to all who enter its doorways. A healthcare facility offers outstanding medical education to future medical professionals in 27 academic disciplines. Critical care and trauma, cardiovascular disease, neurosurgery, diabetes, cancer care, proper care of the destitute and global health are some of the hospital’s recognized special areas of practice. With the Keenan Research Center and also the Li Ka Shing Worldwide Healthcare Education Center, which from the Li Ka Shing Understanding Institute, research and education at St. Michael’s Hospital are recognized making an effect all over the world. Founded in 1892, a healthcare facility is fully associated with the College of Toronto.

New software has respirologists breathing easy


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New software has respirologists breathing easy

Toronto, October 26, 2017

By Kelly O’Brien

Dr. Marie Faughnan (left, in background) and Eva Leek (centre)
Dr. Marie Faughnan (left, in background), director from the Lung Function Lab, and Avoi Leek (center), a respiratory system counselor, brought they that introduced Increase reporting software towards the respirology unit. (Photo by Yuri Markarov)

A respirology team is applying new software to enhance workflow and lower errors in diagnostic reporting within the Lung Function Lab.

The program, produced by Increase Workflow Solutions, extracts patient data from a variety of diagnostic devices and consolidates multiple reports in one reporting software. The report may then be observed rapidly and simply by respirologists along with other caregivers.

Just before installing the program, numerous factors disrupted the workflow, based on Dr. Marie Faughnan, a respirologist and director from the Lung Function Lab.

“In short, we was without a really efficient setup,” she stated.

The Lung Function Lab does an array of tests and every machine creates a different report. With Increase, physicians and staff have access to all a patient’s reports, rather of collecting separate reports from each machine.

“Tests include spirometry, lung volumes, lung diffusing capacity, airway resistance and workout oximetry amongst others,Inches stated Avoi Leek, a respiratory system counselor. “Now, we are able to gather all reports from only one workspace and find out an entire look at the patient’s respiratory system status.”

St. Michael’s is another teaching hospital, there are extra stages in the reporting tactic to accommodate training responsibilities.

      Are you aware?
The Lung Function Lab at St. Michael’s is among largest and busiest in Toronto.

“A report is generated through the Lung Function Lab, would go to the resident after which to the respirologist for review along with a teaching-moment discussion,” stated Dr. Faughnan.

This designed for a workflow which was slow and vulnerable to error. While preliminary reports may be in clinical hands in a day, full diagnostic reports delivered back to referring physicians might take per week or even more to create.

They needed a method which was user-friendly, fast making reports simple to interpret and integrate using the patient’s electronic health record, stated Dr. Faughnan.

The program was integrated using the hospital’s existing cardiology PACS system for fast physician reporting. The brand new system eliminates time-consuming stages in the reporting process, automates old paper-based systems and reduces the opportunity of errors.

Preliminary respiratory system reports now can be found in patients’ electronic charts quickly after being written. Final reports aren’t far behind, frequently turning up within 24 hours.

“It did take us more than expected, what got us through it had been your time and effort everyone in the hospital put in this,” stated Leek. “We stored cooperating in the last year to obtain us where we’re today.”

About St. Michael’s Hospital

St. Michael’s Hospital provides compassionate choose to all who enter its doorways. A healthcare facility offers outstanding medical education to future medical professionals in additional than 29 academic disciplines. Critical care and trauma, cardiovascular disease, neurosurgery, diabetes, cancer care, proper care of the destitute and global health are some of the Hospital’s recognized special areas of practice. With the Keenan Research Center and also the Li Ka Shing Worldwide Healthcare Education Center, which from the Li Ka Shing Understanding Institute, research and education at St. Michael’s Hospital are recognized making an effect all over the world. Founded in 1892, a healthcare facility is fully associated with the College of Toronto.

Literature review finds Canadians in jails and prisons have illness


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Literature review finds Canadians in jails and prisons have illness

Toronto, March 14, 2016

By Leslie Shepherd

Dr. Fiona Kouyoumdjian
Dr. Fiona Kouyoumdjian

Most Canadians in correctional facilities have mental health insurance and drug abuse issues in addition to a high rate of suicide attempts and completions when compared to general population, an extensive overview of studies on detainees’ health finds.

The research brought by Dr. Fiona Kouyoumdjian, a publish-doctorate fellow using the Center for Research on Inner City Health of St. Michael’s Hospital, also found which more than half the folks incarcerated in federal prisons or provincial jails have observed childhood abuse.

“The health of the human population is poor when compared to general Canadian population regarding socioeconomic status, deaths in child custody, mental health, substance use, communicable illnesses and sexual and reproductive health,” stated Dr. Kouyoumdjian. “The amount of time in child custody could give a unique chance to intervene to enhance their own health.Inches

Dr. Kouyoumdjian, an open health physician, examined studies on prisoner/inmate health conducted between 1993 and 2014, in addition to websites of relevant government and non-government organizations, and printed the outcomes today within the journal Canadian Family Physician.

One of the findings:

  • Most individuals correctional facilities have mental health insurance and drug abuse issues. (For instance, 91.7 percent of males in provincial child custody in Edmonton had mental health or drug abuse issues within their lifetime in a single study when compared with 43.7 percent from the general population.)
  • Several in five individuals child custody have attempted suicide.
  • Greater than two-thirds of adults and youth in child custody are smokers, when compared with 16 percent of Canadians. Alcohol consumption is typical within this population, and lots of people begin to use alcohol and drugs in a youthful age.
  • Injection drug abuse is typical, about one out of 10 adults reporting getting injected within the several weeks just before admission and something in 20 youth reporting ever injecting. People continue using drugs in child custody, including by injection.
  • A lot of persons report prior hospitalization for psychological illness –30.1 percent of ladies and 14.5 percent of males accepted to federal child custody in 2007 and 2008.

“As the Un Committee on Torture and also the Correctional Investigator of Canada have known as for that prohibition of segregation for those who have serious mental illness or acute mental illness, using segregation is probably inappropriate for almost all individuals child custody,” Dr. Kouyoumdjian stated.

Many people in child custody experienced major adverse occasions in early childhood, for example witnessing family violence, getting a number of parents absent, or just being associated with the kid welfare system. The vast majority report past childhood physical, sexual, or emotional abuse. About 15 percent to twenty percent of Aboriginal persons in federal facilities have attended residential schools.

The socioeconomic status of the human population is low, as shown by too little housing, low employment rates, low educational achievement, and occasional earnings status. One fifth of males in provincial child custody in Toronto in ’09 and 2010 reported being destitute during the time of admission and most 1 / 2 of youth in child custody in Bc this year and 2013 had have you been destitute. Nearly all adults in child custody haven’t completed senior high school.

In Canada, there are other than 250,000 adult admissions every year to correctional facilities, 8,000 which will be to federal child custody, and 14,000 youth admissions every year. With an average day, there are approximately 40,000 individuals correctional facilities.

This paper is a good example of how St. Michael’s Hospital is making Ontario Healthier, Wealthier, Smarter.

About St. Michael’s Hospital

St. Michael’s Hospital provides compassionate choose to all who enter its doorways. A healthcare facility offers outstanding medical education to future medical professionals in 27 academic disciplines. Critical care and trauma, cardiovascular disease, neurosurgery, diabetes, cancer care, proper care of the destitute and global health are some of the hospital’s recognized special areas of practice. With the Keenan Research Center and also the Li Ka Shing Worldwide Healthcare Education Center, which from the Li Ka Shing Understanding Institute, research and education at St. Michael’s Hospital are recognized making an effect all over the world. Founded in 1892, a healthcare facility is fully associated with the College of Toronto.

Media contacts

To learn more, in order to arrange a job interview with Dr. Kouyoumdjian, please contact:

Leslie Shepherd
Manager, Media Strategy, St. Michael’s Hospital
416-864-6094
[email protected]

Medical student’s painting shows similarities between humans and nature


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Medical student’s painting shows similarities between humans and nature

Toronto, April 4, 2016

By Rebecca Goss

Medical student Mei Wen shows her painting of lungs
Medical student Mei Wen shows her painting of lung area. Click the link or around the photo above to determine a detailed-from the painting. (Photo by Rebecca Goss)

The very first time medical student Mei Wen saw an individual lung it advised her of the tree.

So she did what she usually does when she learns something interesting: she colored.

For Wen, an initial-year College of Toronto medical student who attends her Arts and Science in Clinical Medicine class in the Li Ka Shing Understanding Institute, painting is a method to both decompress and produce to existence concepts she’s learned at school. She bakes an effort to create aside a minumum of one weekend monthly to color and she or he attempts to connect her works of art to her medical studies.

Her newest piece, a 50-centimetre by 60-centimetre acrylic painting entitled Lung Tree, was inspired with a lung she saw in anatomy class.

“The very first time I saw a genuine lung all I possibly could think was just how much it advised me of the tree,” Wen stated. “There a multitude of similarities between our physiques and nature. I love making individuals connections through my art.”

The painting depicts the trachea and bronchi from the lung area like a tree. A corner represents the trachea, the branches represent the bronchi and eco-friendly leaves represent the lobes.

The parrots within the painting symbolize the connections humans need to nature around them. The flowers presents itself the painting are foxgloves, which make the poisonous compound digoxin, frequently utilized as a cardiac stimulant.

      “Not only is the body linked to nature, everything we place in to the physiques, our medicine, is simply too.Inches — Medical student Mei Wen

“It goes full circle,” stated Wen. “Not only is the body linked to nature, everything we place in to the physiques, our medicine, is simply too.Inches

Wen stated Lung Tree was purposefully eye-popping and vibrant to contrast physiological sketches in her own textbooks.

The painting hangs in her own study space in your own home as inspiration to color and also to keep exploring medicine. Another painting of the exterior carotid artery inside a skull hangs nearby. Wen has posted both pieces that need considering for Synesthesia, the College of Toronto Faculty of drugs art show in March.

About St. Michael’s Hospital

St. Michael’s Hospital provides compassionate choose to all who enter its doorways. A healthcare facility offers outstanding medical education to future medical professionals in 27 academic disciplines. Critical care and trauma, cardiovascular disease, neurosurgery, diabetes, cancer care, proper care of the destitute and global health are some of the hospital’s recognized special areas of practice. With the Keenan Research Center and also the Li Ka Shing Worldwide Healthcare Education Center, which from the Li Ka Shing Understanding Institute, research and education at St. Michael’s Hospital are recognized making an effect all over the world. Founded in 1892, a healthcare facility is fully associated with the College of Toronto.

Gamblers Anonymous connected with progress, may need more combined approach: literature review


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Gamblers Anonymous connected with progress, may need more combined approach: literature review

Toronto, April 5, 2016

By Kendra Stephenson

Dr. Flora Matheson
Dr. Flora Matheson

Individuals who attended Gamblers Anonymous gambled less frequently, demonstrated elevated readiness for change that has been enhanced coping skills, but made an appearance to fair better when Gamblers Anonymous was coupled with other therapeutic approaches, an extensive review finds.

Gamblers Anonymous is really a twelve-step program for people having a gambling problem, according to peer support along with a shared need to stop gambling. About 3 to 6 percent of people encounters problem gambling, however the incidence is a lot greater within lower-earnings populations.

“Gamblers Anonymous is among the most cost-effective and simply accessible sources for people coping with problem gambling issues,” stated Dr. Flora Matheson, lead researcher from the study and medical sociologist in the Center for Research on Inner City Health of St. Michael’s Hospital. “However, regardless of the wide-spread utilization of Gamblers Anonymous, there’s been little research exploring its usefulness like a recovery approach, and individuals which have are largely sporadic. We checked out the accessible data to recognize gaps in understanding and provide some insight for future focuses of study.”

The research, printed today in The Journal of Gambling Studies, discovered that the potency of Gambers Anonymous must be studied further, but made an appearance to exhibit better rates of abstinence, improved gambling signs and symptoms and quality of existence, particularly when used along with other approaches, for example stress management intervention and cognitive behavioural therapy.

“Previous studies have proven that lots of people with problem gambling also provide drug abuse or mental health problems, frequently rooted in some kind of earlier trauma,” stated Dr. Matheson. “Gamblers Anonymous provides a safe space that people share their knowledge about other people who understand problem gambling, but maybe doesn’t treat underlying causes associated with gambling. It’s possible other approaches do.”

Review incorporated data from 17 studies on various facets of problem gambling printed between 2002 and 2015 – varying from evaluating treatment effectiveness, to GA culture characteristics and variations in gender encounters.

One of the findings:

  • Greater reductions of depression, panic and anxiety, and elevated existence satisfaction and sleep duration among individuals using Gamblers Anonymous coupled with stress management intervention (includes education on dieting and exercise, stress coping methods, relaxation breathing and progressive muscle relaxation).
  • Gamblers Anonymous participants shown significant reductions in gambling symptom severity in addition to enhancements in psychosocial functioning and excellence of existence using imaginal desensitization plus motivational interviewing, or IDMI.
  • Greater enhancements in gambling signs and symptoms and reduced days gambled when GA was coupled with cognitive behavioural therapy.
  • Overall improved coping skills in Gamblers Anonymous attendees, better leads to individuals also taking part in cognitive behavioural therapy.

Additionally to reviewing literature on the potency of Gamblers Anonymous, they examined variations in gender encounters using the program. Women appeared to profit from Gamblers Anonymous around men initially, viewing it as being an origin of expect their problem gambling. However, women used Gamblers Anonymous to build up informal social systems outdoors from the program along with other women attending Gamblers Anonymous – a method essential for women’s recovery, in addition to professional therapies.

“Gamblers Anonymous remains a practical and accessible option for those who have problem gambling, nevertheless its effectiveness alone like a treatment option must be evaluated comprehensively to find out any gaps and improve take care of these people,Inches stated Dr. Matheson.

This research received funding in the Ontario Problem Gambling Research Center.

This paper is a good example of how St. Michael’s Hospital is making Ontario Healthier, Wealthier, Smarter.

About St. Michael’s Hospital

St. Michael’s Hospital provides compassionate choose to all who enter its doorways. A healthcare facility offers outstanding medical education to future medical professionals in 27 academic disciplines. Critical care and trauma, cardiovascular disease, neurosurgery, diabetes, cancer care, proper care of the destitute and global health are some of the hospital’s recognized special areas of practice. With the Keenan Research Center and also the Li Ka Shing Worldwide Healthcare Education Center, which from the Li Ka Shing Understanding Institute, research and education at St. Michael’s Hospital are recognized making an effect all over the world. Founded in 1892, a healthcare facility is fully associated with the College of Toronto.

Media contacts

To learn more in order to arrange a job interview with Dr. Matheson, please contact:

Kendra Stephenson
Communications Consultant – Media
416-864-5047
[email protected]

Enhance your hands-hygiene education: Are you currently a difficult Scrubber?


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Enhance your hands-hygiene education: Are you currently a difficult Scrubber?

Toronto, October 16, 2017

Through the Heart and Vascular Program’s Quality and Safety Leaders Group

OT Laura Shapiro and PT Rebecca Bunston
Work-related counselor Laura Shapiro (left) and physio therapist Rebecca Bunston (right) helped develop Tough Scrubber at St. Michael’s.

Fun, fast, challenging, amusing. Is that this the way your staff would describe their hands-hygiene education? Try Tough Scrubber plus they might just.

Within the St. Michael’s Heart and Vascular Program, our traditional hands hygiene interventions were feeling a little stale. Engagement was low – and honestly, it demonstrated within our compliance rates.

We wanted greater than a poster. We wanted a sensation! Enter Tough Scrubber, the creation in our program’s Quality and Safety Leaders Group. A experience the challenging Mudder concept, front-line staff undergo a quick-paced, over-the-top simulation that’s targeted at their clinical area. There is a quick quiz before they begin along with a quick debrief once they finish… and that’s it. The entire process takes ten minutes or fewer. We’re pleased to report, it had been an enormous hit!

This five-minute video will explain much more about how Tough Scrubber works. We’ve also come up with a toolkit to assist hands-hygiene champions implement Tough Scrubber in their own individual hospitals and health-care organizations.

For the staff, Tough Scrubber opened up the doorway to a different thought process about hands hygiene. It’s Alright to inquire and also to provide your colleagues feedback – we’re all learning. Doing hands hygiene properly can be hard, but it’s much simpler whenever we help one another out.

Tough Scrubber toolkit cover

Download our toolkit

Up to now, 43 Heart and Vascular staff have finished Tough Scrubber, and our hope is you will too. It just takes our toolkit, 4-5 hands-hygiene leaders (to operate the game and pose as patients), a clear patient room with two beds, and also the everyday equipment described within the scenarios (e.g. a motorized wheel chair, a basin).

Within our Heart and Vascular Units, we’ve improved our compliance rate for Moment 1 by 27% in 3 years. This is really the effect of a mixture of many years of education, effort and many different types of interventions. However our Tough Scrubber sessions truly felt such as the tipping point.

For additional info on Tough Scrubber and also to download the toolkit, visit world wide web.stmichaelshospital.com/toughscrubber.

Check it out, and tell us the way it labored for you personally! For those who have any queries or feedback, please call us at [email protected] and [email protected]

About St. Michael’s Hospital

St. Michael’s Hospital provides compassionate choose to all who enter its doorways. A healthcare facility offers outstanding medical education to future medical professionals in additional than 29 academic disciplines. Critical care and trauma, cardiovascular disease, neurosurgery, diabetes, cancer care, proper care of the destitute and global health are some of the Hospital’s recognized special areas of practice. With the Keenan Research Center and also the Li Ka Shing Worldwide Healthcare Education Center, which from the Li Ka Shing Understanding Institute, research and education at St. Michael’s Hospital are recognized making an effect all over the world. Founded in 1892, a healthcare facility is fully associated with the College of Toronto.

Women with unhealthy BMIs who smoke and drink at two-fold greater chance of bronchial asthma: worldwide study


Our Tales

Women with unhealthy BMIs who smoke and drink at two-fold greater chance of bronchial asthma: worldwide study

Toronto, April 6, 2016

By Kendra Stephenson

Dr. Jayadeep Patra
Dr. Jayadeep Patra

Underweight and obese ladies who also drank alcohol and smoked tobacco were built with a two-fold greater chance of being identified as having bronchial asthma than women with a sound body mass index who didn’t drink or smoke, a St. Michael’s Hospital study found.

Women with high and low weight indexes, or BMIs, who smoked and drank were also 2 to 3 occasions more prone to experience wheezing.

Bronchial asthma is really a respiratory system condition where spasms in mid-air pathways from the lung area cause breathlessness usually triggered by an allergic reaction or sensitivity within the atmosphere. Bronchial asthma is really a global health priority because of the extent and time period of disability, affecting 334 million people worldwide.

The research, printed now in BMJ Open Respiratory system Research, is the first one to measure the combined results of Body mass index, smoking, consuming alcohol and solid fuel experience the chance of developing bronchial asthma. The study incorporated data collected between 2002 and 2004 from roughly 175,000 people aged 18 to 44, across 51 countries.

“Although individual physical and behavior factors connected with bronchial asthma happen to be examined before, individuals are frequently uncovered to multiple risks so it’s important we know the combined impact,” stated Dr. Jayadeep Patra, lead author from the study as well as an epidemiologist in the Center for Global Health Research of St. Michael’s Hospital. “Our research found overall elevated risk for wheezing and bronchial asthma in both women and men, however the magnitude from the combined effects from low or high Body mass index, smoking and consuming was consistently greater among women than men.”

Men demonstrated greater prevalence of smoking and employ of alcohol than women, but more women had unhealthy BMIs (underweight or obese) than men, highlighting the higher impact of female Body mass index like a risk factor.

Dr. Patra also noted you will find significant variations in diagnosed bronchial asthma between countries, with growing rates present in low-earnings and middle-earnings countries, potentially due to greater contact with multiple risks, including using solid fuel.

In low and middle-earnings countries, solid fuels for example dung, charcoal or wood can be used for cooking and therefore are common in lots of households. These fuels are recognized to lead to greater chance of developing respiratory system and coronary disease, when compared with those who prepare with electric or gas devices.

“In the past few years, the increasing health insurance and economic burden of non-infectious respiratory system illnesses for example bronchial asthma have presented a substantial challenge to public health,” stated Dr. Patra. “Respiratory illnesses are complex, with multiple genetic, ecological and behavioural risks that fluctuate across regions and affect particular populations diversely.Inches

Dr. Patra stated the combined results of identified risks haven’t been sufficiently studied by yet, with lots of questions still unanswered. For instance, contact with polluting of the environment or second-hands smoke in lower earnings countries could lead to greater rates of bronchial asthma and respiratory system issues, however this information wasn’t available throughout the current study. Also, countries with greater male smoking rates for example India or Bangladesh could impact on greater bronchial asthma and wheezing rates because of more contact with second-hands smoke.

“The impact of those factors combined on wheezing signs and symptoms and diagnosed bronchial asthma requires greater focus on collaborative – instead of isolated – efforts to lower their exposure,” stated Dr. Patra. “The effect on the significant population particularly is every bit important, which suggests another potential section of focus for future intervention strategies.”

This research was funded through the US National Institutes of Health, the Canadian Institutes of Health Research and also the Bill and Melinda Gates Foundation.

This paper is a good example of how St. Michael’s Hospital is making Ontario Healthier, Wealthier, Smarter.

About St. Michael’s Hospital

St. Michael’s Hospital provides compassionate choose to all who enter its doorways. A healthcare facility offers outstanding medical education to future medical professionals in 27 academic disciplines. Critical care and trauma, cardiovascular disease, neurosurgery, diabetes, cancer care, proper care of the destitute and global health are some of the hospital’s recognized special areas of practice. With the Keenan Research Center and also the Li Ka Shing Worldwide Healthcare Education Center, which from the Li Ka Shing Understanding Institute, research and education at St. Michael’s Hospital are recognized making an effect all over the world. Founded in 1892, a healthcare facility is fully associated with the College of Toronto.

Media contacts

To learn more in order to arrange a job interview with Dr. Patra, please contact:

Kendra Stephenson
Communications Consultant – Media
416-864-5047
[email protected]

Many ICU patients trade their critical illness for brand new and debilitating illness, ICU-acquired weakness


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Many ICU patients trade their critical illness for brand new and debilitating illness, ICU-acquired weakness

Toronto, April 8, 2016

By Leslie Shepherd

Dr. Jane Batt
Dr. Jane Batt

An increasing number of people are being discharged from intensive care units, cured from the critical illness that place them there but facing a brand new and potentially debilitating condition — ICU-acquired weakness.

Intensive care patients are recognized to lose muscle tissue and performance for a lot of reasons, varying from prolonged immobilization, towards the results of ICU treatments for example mechanical ventilation towards the critical illness itself.

As the mechanisms of muscle atrophy (loss) and performance throughout an ICU stay happen to be studied well, little studies have been conducted in to the cellular and molecular mechanisms accountable for recovering muscle strength within the lengthy-term.

New research printed today within the American Journal of Respiratory system and demanding Care Medicine discovered that some patients who continue to be affected by weakness six several weeks once they were discharged in the ICU, demonstrate persistent muscle wasting, even if your biologic functions that generally cause muscles to atrophy have came back to normalcy for example inflammation or even the introduction to proteins in muscle tissues.

In addition, there’s no be certain that reconstitution of muscle size normalizes strength patients who were able to regrow muscle continued to be weak. In some instances, this muscle weakness causes profound disability and reduced quality of existence, and may serve you for a lifetime, stated the study’s lead author, Dr. Jane Batt, a respirologist at St. Michael’s Hospital.

“We know ICU patients lose muscle tissue and performance. Critical illness literally causes their muscles to dissolve,” stated Dr. Batt, a researcher within the hospital’s Keenan Research Center for Biomedical Science. “Some people fill it up back and a few don’t. Many people can regrow muscle, however it doesn’t function correctly.”

Dr. Batt stated the novel finding of her study was that sustained muscle atrophy within the lengthy term is caused by impaired regrowth and it is connected with home loan business the amount of satellite cells, the precursors to muscle tissues.

“While satellite cells aren’t needed for existing muscle fibres to develop in dimensions, they’re required for the regeneration of hurt muscle,” she stated. Decreased quantity of satellite cells also lead to age-related muscle loss, she noted.

“Critical illness seems to permanently change muscle biology so that your regenerative capacity appears to become lost,” she stated.

Dr. Batt stated ICU-acquired weakness could be a profound disability.

“You may be unable to bathe yourself, feed yourself, visit the toilet yourself, dress yourself,” she stated. “This could be a very difficult existence to reside.Inches

Dr. Batt’s study checked out critically ill patients who’d spent a minumum of one week on the ventilator within an ICU. The research may be the first phase from the MEND ICU research program, spearheaded by Dr. Batt and Dr. Claudia dos Santos, an intensivist at St. Michael’s. It belongs to the RECOVER program, a multi-center study that evaluates patient and caregiver outcomes after prolonged mechanical ventilation having a objective of creating a family-centred rehabilitation program after severe critical illness.

The amount of patients within the study was small, Dr. Batt acknowledged. She stated this reflected the problem in finishing lengthy-term mechanistic studies with individuals who experience critical illness, as numerous of individuals who wanted to get familiar with the research, died, had to go back to the ICU, or developed other serious medical conditions necessitating treatment that precluded safe continuation within the study.

A study was printed within the American Journal of Respiratory system and demanding Care Medicine in March through the RECOVER program lead, Dr. Margaret Herridge of Toronto General Hospital. That study discovered that critically ill patients who spend several week on ventilation could be split into four risk groups which the quality of disability 7 days after discharge determines the main one-year mortality and recovery trajectory, including ICU and hospital readmission. The older the individual, the more serious the disability, this research found, even though the first risk group was patients within their early 40s.

Dr. Batt’s study received funding in the Canadian Institutes of Health Research, Physician Services Incorporated Foundation and also the Ontario Thoracic Society.

This paper is a good example of how St. Michael’s Hospital is making Ontario Healthier, Wealthier, Smarter.

About St. Michael’s Hospital

St. Michael’s Hospital provides compassionate choose to all who enter its doorways. A healthcare facility offers outstanding medical education to future medical professionals in 27 academic disciplines. Critical care and trauma, cardiovascular disease, neurosurgery, diabetes, cancer care, proper care of the destitute and global health are some of the hospital’s recognized special areas of practice. With the Keenan Research Center and also the Li Ka Shing Worldwide Healthcare Education Center, which from the Li Ka Shing Understanding Institute, research and education at St. Michael’s Hospital are recognized making an effect all over the world. Founded in 1892, a healthcare facility is fully associated with the College of Toronto.

Media contacts

To learn more in order to arrange a job interview with Dr. Batt, please contact:

Leslie Shepherd
Manager, Media Strategy, St. Michael’s Hospital
416-864-6094
[email protected]

More male babies than expected being born to Indian-born women residing in Canada, two research papers find


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More male babies than expected being born to Indian-born women residing in Canada, two research papers find

Toronto, April 11, 2016

By Leslie Shepherd

Dr. Marcelo Urquia
Dr. Marcelo Urquia

More male babies than expected are born to Indian-born women residing in Canada who curently have several children, based on research printed today within the journal CMAJ Open.

This gender imbalance has been in existence not less than 2 decades and could be seen across Canada, stated lead author Dr. Marcelo Urquia of St. Michael’s Hospital.

The research, which used Statistics Canada data, highlights the “magnitude from the skewed sex ratios” among Indian immigrants but doesn’t explain why this imbalance exists, stated Dr. Urquia, an epidemiologist within the hospital’s Center for Research on Inner city Health.

However, another paper by Dr. Urquia printed today within the Canadian Medical Association Journal discovered that more boys were born to Indian-born women residing in the province of Ontario when they already had two women. The sex ratio elevated considerably when they had one abortion just before their third birth, when they had several abortion, and when they’d an abortion after 14 days pregnancy once the sex from the fetus can precisely be based upon an ultrasound.

Dr. Urquia stated these 4 elements likely described the gender imbalance in the remainder of Canada too.

In the majority of the world, between 103 and 107 boys are born for each 100 women. Canadian-born women residing in Canada delivered about 105 boys for each 100 women, Dr. Urquia’s paper found.

But women born in India, who curently have two children, delivered 138 baby boys in Canada for each 100 women. If they have three children, they provide birth to 166 boys for each 100 women.

Couples involving a minumum of one Indian-born parent delivered more boys than women in second and then births, primarily once the father was created in India.

Dr. Urquia stated it was the very first paper to look at both mother and father’s country of origin when analyzing sex ratios.

His national study examined birth record data of 5.8 million births to Canadian-born ladies and 177,990 Indian-born women between 1990 and 2011. The information is supplied by provincial Vital Statistics Registrars towards the Canadian Vital Statistics Birth Database administered by Statistics Canada.

In Ontario, data housed through the Institute for Clinical Evaluative Sciences also demonstrated sex rations among babies of Canadian-born women were inside the expected range.

However, women born in India who already had two kids then give birth to 196 boys for each 100 women.

  • The sex ratio increases to 326 boys for each 100 women when the Indian-born mother with two kids had an abortion preceding the 3rd birth.
  • It increases to 409 boys for each 100 women when the mother had several abortion.
  • Also it increases again to 663 boys for each 100 women when the mother had a minumum of one abortion after 14 days of pregnancy once the sex from the fetus could be precisely believed by ultrasound.

The CMAJ study examined 1.two million births to women with as many as three live births between 1993 and 2012 in Ontario, where abortions are generally legal and free. Records of live births and abortions were associated with Canadian immigration records.

Dr. Urquia stated the information utilized in his studies didn’t indicate how lengthy Indian immigrants had resided in Canada and whether that impacted the sex ratio. Nor made it happen indicate country of origin from the babies’ grandma and grandpa, meaning a few of the Canadian-born moms might have been second-generation immigrants.

“We conservatively believed that 4,472 women of Indian immigrants to Canada were unaccounted for during the last 2 decades, largely among couples of two Indian-born parents but additionally among couples which have one Canadian-born parent,” Dr. Urquia stated.

The Ontario study also found a small imbalance in the amount of boys born to Chinese-born women residing in Canada, but it wasn’t associated with abortion and appeared to become much more about family balancing.

The CMAJ Open study received funding in the Canadian Research Data Center Network, the Social Science and Humanities Research Council, the Canadian Foundation for Innovation and Statistics Canada. The CMAJ study received funding in the Canadian Institutes of Health Research.

This paper is a good example of how St. Michael’s Hospital is making Ontario Healthier, Wealthier, Smarter.

About St. Michael’s Hospital

St. Michael’s Hospital provides compassionate choose to all who enter its doorways. A healthcare facility offers outstanding medical education to future medical professionals in 27 academic disciplines. Critical care and trauma, cardiovascular disease, neurosurgery, diabetes, cancer care, proper care of the destitute and global health are some of the hospital’s recognized special areas of practice. With the Keenan Research Center and also the Li Ka Shing Worldwide Healthcare Education Center, which from the Li Ka Shing Understanding Institute, research and education at St. Michael’s Hospital are recognized making an effect all over the world. Founded in 1892, a healthcare facility is fully associated with the College of Toronto.

Media contacts

To learn more in order to arrange a job interview with Dr. Urquia, please contact:

Leslie Shepherd
Manager, Media Strategy, St. Michael’s Hospital
416-864-6094
[email protected]